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IV Ketamine at The Linden Medical Centre

The Linden Medical Centre provides IV Ketamine to patients suffering from major depression. We are proud to offer this research-backed modern treatment to patients who have not had positive results with first-line antidepressant medications.

We are the first private clinic in Western Canada to offer IV Ketamine Therapy for depression.

An approved non-hospital treatment facility is needed to administer an IV anesthetic. Although we use a sub-anaesthetic dose of Ketamine to treat depression, Ketamine is an anaesthetic drug. Our facility continues to meet the high safety standards set out by the CPSS for non-hospital treatment facilities.

An Exceptional team is an essential aspect of IV Ketamine therapy. The care team includes both a psychiatrist and an anesthesiologist. A psychiatrist follows our patients’ psychiatric illness. An anesthesiologist and an ACLS trained registered nurse ensure each ketamine treatment is safely delivered.

Book Online

Click the button below to book a telephone, or in person consult to discuss ketamine for depression.

**Be sure to select Zach Macnab as a provider when booking an appointment online**

Physician Referrals

Click the button below if you are a physician who would like to refer a patient to us to discuss IV Ketamine, or rTMS.

IV Ketamine

IV Ketamine Therapy FAQ

The following is a list of frequently asked questions about IV Ketamine treatments at The Linden Medical Centre.

How Does Ketamine for Depression Work?

Traditional antidepressant medication modulates neuron messaging by preventing the re-absorption of serotonin and norepinephrine.  This can result in improved communication between nerve cells and stronger circuits that regulate mood.  Unfortunately, these medications don’t work for everyone.

BDNF (brain-derived neurotrophic factor) is a protein that supports the survival of existing neurons and encourages the growth of dendrites and synapses.  Life stressors and past traumas can inhibit the production of BDNF and predispose people to serious mood and anxiety disorders.

Ketamine acts as an antagonist at the NMDA receptor and blocks the receptor from reabsorbing glutamate.  This causes the release of BDNF which helps promote neuronal connectivity.  It is believed that this is the mechanism of ketamine’s antidepressant effects.

Who can get Ketamine for Depression?

IV ketamine infusion therapy is an option for adult (>18 years) patients with refractory major depressive disorder who have not responded to trials of 2 or more antidepressants.  It is contraindicated in patients with unstable cardiovascular disease, psychosis or a history of ketamine abuse

What Happens After I'm Referred?

Your first appointment is a consultation with a Registered Nurse.  They will clarify your mental and physical health history and answer any questions you have.  He or she will then discusses your case with the psychiatrist to determine if you are an appropriate candidate for IV Ketamine therapy.

Do I need to travel to Saskatoon for my initial Consult?

We require an initial screening consult to ensure ketamine is appropriate for your case.  This is normally done at our office, but if you have a long distance to travel, this can be a video consult.  For video consults, we’ll need your email address, and you’ll need access to a device or computer with a camera.  At your appointment time, simply follow the link in your email, and click on the button that says “join on the web instead”.  There is no need to install software on your device.

What Are IV Ketamine Treatments Like?

When you arrive for your infusion, an RN will bring you to a private treatment room.  You will meet the anesthetist, who will be administering the medication and monitoring your blood pressure, heart rate and oxygen saturation.  An intravenous line (IV) will be started in an extremity and you will be given a weight-based, sub-anesthetic dose of ketamine by continuous infusion over 40 minutes. Depending upon your response to the first infusion, the dose of ketamine or the duration of the infusion may be changed to maximize your response.

Our treatment rooms have blankets, pillows and dimmable lighting for your comfort.  You can bring a mobile device to listen to music with earbuds or use our Bluetooth speaker.  Family members or friends are welcome to stay with you during the infusion.

How Many Ketamine Infusions Will I Need?

For some, a single infusion of ketamine will produce the desired response, but most patients require a full course of treatments.  Our clinic recommends 2 infusions per week for 3 weeks for a total of 6 treatments.

How Long Will I Stay Well After a Course of Infusions?

The length of symptom remission varies but the average is 4-6 weeks.  We recommend returning for a single infusion booster when you feel it is necessary.  Some patients find that over time they can go longer and longer between booster treatments.

What Are The Side Effects of IV Ketamine Therapy?

The most common side effect of ketamine is dissociation, which is when images appear somewhat distorted. Dissociation affects up to a third of people during the first infusion. The number of people who experience dissociation decreases with each subsequent infusion.

Other common side effects include headache, nausea, dizziness, blurred vision, drowsiness, elevated mood, anxiety, and elevations in blood pressure and heart rate.  All the side effects are transient and resolve quickly post-infusion.

An uncommon side effect of ketamine is cystitis or hematuria.  This is typically associated with prolonged ketamine abuse but please inform us if you experience bladder pain or blood in your urine.

Are There Any Risks With Ketamine Treatments?

Any time a medication is administered via IV there are risks such as discomfort from the needle stick, bruising, and infection at the IV site.  Dosing errors, or drug interactions that require medical intervention such as intubation or hospitalization could also occur.

The other risk is that ketamine may not help your depression, PTSD, or suicidal ideation.

What precautions must I take?

  • You must not drive a car, operate hazardous equipment, or engage in hazardous activities for 24 hours after each treatment as reflexes may be slow or impaired.
  • Plan to not conduct business or make any critical decisions for the remainder of the day after an infusion.
  • You must refrain from consuming alcohol or other recreational drugs for 24 hours before and 24 hours after an infusion.
  • You must inform The Linden Medical Centre of all prescription medications, and over the counter supplements you are taking.

Where else can I get IV Ketamine for depression?

The following are links to other ketamine clinics in Canada.

Canadian Rapid Treatment Centre of Excellence

Field Trip Health

Novaket Infusion Clinic

What Is The Cost of The Ketamine Treatments?

Individual treatments cost $525.  A full treatment course (6 treatments over 3 weeks) is $3150. No part of this service is covered by Saskatchewan Healthcare but your 3rd party insurance agency may cover a portion of the cost.  We do not direct bill insurance companies, but will gladly provide an invoice and the drug identification number (DIN) to submit with your claim.


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